abstract：OBJECTIVES:Interindividual variability in intestinal absorption and bioavailability might contribute to inadequate control of seizures under treatment with carbamazepine and phenytoin. We therefore correlated intestinal expression levels and genetics of CYP3A4, CYP2C9/19, MDR1 and MRP2 with dose requirement and plasma ...

journal_title：Acta neurologica Scandinavica

authors： Simon C,Stieger B,Kullak-Ublick GA,Fried M,Mueller S,Fritschy JM,Wieser HG,Pauli-Magnus C

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, tumor necrosis factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease. MATERIALS AND METHODS:Two hundred an...

journal_title：Acta neurologica Scandinavica

authors： Kamali-Sarvestani E,Nikseresht A,Aflaki E,Sarvari J,Gharesi-Fard B

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To prospectively detect significant transient F wave abnormalities obtained after exercise in patients with peripheral arterial disease (PAD) and to assess the potential diagnostic sensitivity of dynamic F wave study in such a context. PATIENTS AND METHODS:A series of 40 electrical stimuli were delivered to ...

journal_title：Acta neurologica Scandinavica

authors： Argyriou AA,Tsolakis I,Papadoulas S,Polychronopoulos P,Gourzis P,Chroni E

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:To provide an update on recent research concerning obstructive sleep apnea syndrome (OSAS) and executive functions. METHODS:A systematic review was carried out on reports drawn from MEDLINE and PSYCHLIT (January 1990-December 2005) and identified from lists of references in these reports. The selection crit...

journal_title：Acta neurologica Scandinavica

authors： Saunamäki T,Jehkonen M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To determine whether variants in the Slit and Trk-like 1 gene (SLITRK1) are present in American Caucasian population of patients with Tourette syndrome (TS). METHODS:We sequenced the 3'-untranslated region for var321 and the whole coding region in the SLITRK1 gene in 82 Caucasian patients with TS from North ...

journal_title：Acta neurologica Scandinavica

authors： Deng H,Le WD,Xie WJ,Jankovic J

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:We examined whether the apolipoprotein E (ApoE) allele epsilon4 influences imaging findings in stroke as assessed by diffusion- (DWI) and perfusion-weighted (PWI) magnetic resonance imaging, and MR angiography (MRA). METHODS:Eight ApoE epsilon4 carriers and 15 non-carriers with acute ischemic stroke in the ...

journal_title：Acta neurologica Scandinavica

authors： Liu Y,Nuutinen J,Laakso MP,Karonen JO,Soimakallio S,Aronen HJ,Vanninen RL

更新日期：2006-11-01 00:00:00

abstract：:Once believed to be extremely uncommon, due to magnetic resonance imaging cavernous hemangiomas of the spinal cord are detected with increasing frequency. Management of both symptomatic and asymptomatic intramedullary cavernous hamangiomas is therefore of growing importance. However, experience with treatment and foll...

journal_title：Acta neurologica Scandinavica

authors： Kondziella D,Brodersen P,Laursen H,Hansen K

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:The Flt3 ligand (FL) is a cytokine with a neurotrophic and antiapoptotic activity in the central nervous system that induces the survival of neurons. The aim of the study was to measure levels of FL in amyotrophic lateral sclerosis (ALS) patients. MATERIALS AND METHODS:The study involved 23 ALS patients and...

journal_title：Acta neurologica Scandinavica

authors： Iłzecka J

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI). METHODS:Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinical...

journal_title：Acta neurologica Scandinavica

authors： Ishiwata A,Sakayori O,Minoshima S,Mizumura S,Kitamura S,Katayama Y

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies. MATERIALS AND METHODS:In this observational study, 1,428 patients were included who had stroke and were admitted to our Stroke Unit between the years 1996 an...

journal_title：Acta neurologica Scandinavica

authors： Benbir G,Ince B,Bozluolcay M

更新日期：2006-07-01 00:00:00

abstract：:The spontaneous occurrence of blepharospasm and dystonic movements in face muscles, particularly those of the perioral and mandibular regions, has been named as Meige's disease which was first described by Henry Meige in 1910. We report the case of a woman with Meige's syndrome whose symptoms improved with the use of ...

journal_title：Acta neurologica Scandinavica

authors： Yardimci N,Karatas M,Kilinc M,Benli S

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The reported sensitivity of transcranial Doppler ultrasonography (TCD) for confirming brain death (BD) ranges from 91% to 100%. We assessed the frequency and causes of false-negative results in TCD examination in a series of patients with BD and in the literature. METHODS:We carried out a prospective TCD exa...

journal_title：Acta neurologica Scandinavica

authors： de Freitas GR,André C

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:We investigated whether mutation of mitochondrial DNA (mtDNA) affects the copy number of the mitochondrial genome in patients with mitochondrial myopathy encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and those with myoclonic epilepsy with ragged-red fiber (MERRF) syndromes. MATERIALS ...

journal_title：Acta neurologica Scandinavica

authors： Liu CS,Cheng WL,Lee CF,Ma YS,Lin CY,Huang CC,Wei YH

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:To determine whether Parkinson's disease (PD) can be distinguished from multiple system atrophy (MSA) on the basis of the assessment of iodine-123 meta-iodobenzylguanidine (123I-MIBG) radioactivity in heart and cardiovascular autonomic function. PATIENTS AND METHODS:Seventeen patients with MSA, 39 with PD, ...

journal_title：Acta neurologica Scandinavica

authors： Oka H,Mochio S,Yoshioka M,Morita M,Onouchi K,Inoue K

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to examine the effects of D-amphetamine (D-amph) and physical therapy separately or combined on fine motor performance, gross motor performance and cognition after middle cerebral artery thromboembolization in rats. METHODS:Seventy-four rats were trained in appropri...

journal_title：Acta neurologica Scandinavica

authors： Rasmussen RS,Overgaard K,Hildebrandt-Eriksen ES,Boysen G

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:To assess the correlation of diffusion-weighted (DWI) and perfusion-weighted imaging (PWI) findings with the severity of acute neurologic deficit and their ability to predict short and long-term clinical outcomes of stroke. The ability of DWI and PWI to predict the outcome was compared with the ability of cl...

journal_title：Acta neurologica Scandinavica

authors： Nuutinen J,Liu Y,Laakso MP,Karonen JO,Roivainen R,Vanninen RL,Partanen K,Østergaard L,Sivenius J,Aronen HJ

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Persons who have suffered from acute poliomyelitis may decades later experience reduction of balance and gait capacity due to muscle weakness, fatigue and/or pain. This may affect the activity level in daily life of these persons. AIMS OF THE STUDY:The aim of this study was to describe observer assessed and...

journal_title：Acta neurologica Scandinavica

authors： Lehmann K,Sunnerhagen KS,Willén C

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The clinical differentiation between early Parkinson's disease (PD) and essential tremor (ET) could be difficult, therefore, the aim of this study was to investigate 99mTc-TRODAT-1 SPECT as an applicable tool in this field. METHODS:99mTc-TRODAT-1 single photon emission computed tomography (SPECT) was perform...

journal_title：Acta neurologica Scandinavica

authors： Wang J,Jiang YP,Liu XD,Chen ZP,Yang LQ,Liu CJ,Xiang JD,Su HL

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:After surgery for ruptured anterior communicating artery (ACoA) aneurysm, several patients who have achieved a favorable neurological outcome yet have been observed to suffer from a poor cognitive outcome. The aim of this study was to explore the possible effects of temporary clip applications on frontal lob...

journal_title：Acta neurologica Scandinavica

authors： Akyuz M,Erylmaz M,Ozdemir C,Goksu E,Ucar T,Tuncer R

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:To characterise a Swedish family with a rare hereditary myopathy with unique sarcoplasmic inclusion bodies in the muscle biopsy. MATERIALS AND METHODS:Part of the pedigree was described in 1980. Nine new members of the included and the phenotype further characterised through clinical, neurophysiological and...

journal_title：Acta neurologica Scandinavica

authors： Engvall M,Ahlberg G,Hedberg B,Edström L,Ansved T

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVES:We performed nerve conduction and needle electromyographic tests in 29 patients with spastic cerebral palsy (SCP) and severe limb deformities. Nerve conduction abnormalities were detected in 32 of 400 sensory or motor nerves, while 11 of 29 patients (37.9%) showed abnormal nerve conduction, indicating one or...

journal_title：Acta neurologica Scandinavica

authors： Frascarelli M,Frascarelli F,Gentile MG,Serrao M,De Santis F,Pierelli F,Santilli V

更新日期：2005-09-01 00:00:00

abstract：:In Sweden, the annual incidence of surgery for hydrocephalus was 3.4 per 100,000 adults between the years 1996 and 1998. The most common indication for surgery was normal pressure hydrocephalus (NPH; 47%), followed by high-pressure hydrocephalus (27%). Seventy-three percent of the patients had communicating hydrocepha...

journal_title：Acta neurologica Scandinavica

authors： Tisell M,Höglund M,Wikkelsø C

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:To assess predictors of headache in patients who had sustained a head injury 22 years earlier. MATERIALS AND METHODS:A questionnaire about headache was sent to 361 subjects hospitalized for head injury in 1974-1975. RESULTS:A total of 249 patients (69%) responded to the questionnaire. The prevalence of hea...

journal_title：Acta neurologica Scandinavica

authors： Nestvold K,Lundar T,Mowinckel P,Stavem K

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 is an autosomal dominant spinocerebellar degeneration, for which there is no effective treatment. PATIENTS AND METHODS:This study involved the clinical response of lamotrigine (LTG) on six MJD patients with early truncal ataxia and the effect of LTG ...

journal_title：Acta neurologica Scandinavica

authors： Liu CS,Hsu HM,Cheng WL,Hsieh M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:To determine headache characteristics in the obstructive sleep apnea syndrome (OSAS) and in insomnia. PATIENTS AND METHODS:Fifty-six OSAS patients and 50 insomnia patients were assessed in the same time period. Patients in both groups underwent an accurate interview to investigate headache occurrence and it...

journal_title：Acta neurologica Scandinavica

authors： Alberti A,Mazzotta G,Gallinella E,Sarchielli P

更新日期：2005-05-01 00:00:00

abstract：:The association of cortical tremor, myoclonus and epileptic seizures has been reported in many Japanese and European families with different acronyms. We reviewed the familial cases presenting the clinical picture of autosomal dominant cortical tremor, myoclonus and epilepsy and analysed the phenotypic differences bet...

journal_title：Acta neurologica Scandinavica

authors： Striano P,Zara F,Striano S

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Analysis of the CTG-repeat number and three biallelic markers, Alu(+/-), HinfI(+/-), and TaqI(+/-), in the DMPK gene in healthy and myotonic dystrophy type 1 (DM1) Serbian individuals. Also, the consideration of haplotypes in the light of the proposed models of CTG-repeat evolution and origin of the DM1 muta...

journal_title：Acta neurologica Scandinavica

authors： Krndija D,Savić D,Mladenović J,Rakocević-Stojanović V,Apostolski S,Todorović S,Romac S

更新日期：2005-04-01 00:00:00

abstract：:Three Alzheimer's disease patients with Pisa syndrome were presented. These patients were treated with cholinesterase inhibitors within a post-marketing surveillance study. The clinical and pharmacological histories of these patients suggest a relation between cholinesterase inhibitors and the pleurothotonus. The diff...

journal_title：Acta neurologica Scandinavica

authors： Vanacore N,Suzzareddu G,Maggini M,Casula A,Capelli P,Raschetti R

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the epidemiological and clinical features of motor neuron disease (MND) in a region (835,000 inhabitants) of south-western Greece. PATIENTS AND METHODS:The medical records of all patients diagnosed with adult-onset MND at the Department of Neurology of the University Hospital of Patras from 1990 ...

journal_title：Acta neurologica Scandinavica

authors： Argyriou AA,Polychronopoulos P,Papapetropoulos S,Ellul J,Andriopoulos I,Katsoulas G,Salakou S,Chroni E

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQL) has become an important outcome criterion of medical interventions, but was hardly studied in patients with facial spasms. MATERIALS AND METHODS:Patients with blepharospasm or hemifacial spasm treated with botulinum toxin were included. A healthy control group sociodemo...

journal_title：Acta neurologica Scandinavica

authors： Reimer J,Gilg K,Karow A,Esser J,Franke GH

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Multiple sclerosis (MS) is believed to be an autoimmune disease of the human central nervous system mediated by autoreactive T cells. Interferon-beta1b (IFN-beta1b) has been shown to be effective in reducing disease activity defined by clinical and magnetic resonance imaging (MRI) criteria in relapsing-remit...

journal_title：Acta neurologica Scandinavica

authors： Chatzimanolis N,Kraus J,Bauer R,Engelhardt B,Bregenzer T,Kuehne BS,Tofighi J,Laske C,Stolz E,Blaes F,Voigt K,Traupe H,Kaps M,Oschmann P

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:To explore (1) effects of test and subject variables in determining euphoric and dysphoric responses during unilateral amobarbital anesthesia and (2) which cerebral areas contribute to the emotional responses. METHOD:Incidence of euphoric and dysphoric reactions during left- and right-sided amobarbital anes...

journal_title：Acta neurologica Scandinavica

authors： Stabell KE,Andresen S,Bakke SJ,Bjørnaes H,Borchgrevink HM,Heminghyt E,Røste GK

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:Cerebral hypoperfusion has been evidenced in patients with periventricular white matter lucency (PWML), however, our knowledge is limited regarding vasoreactivity (VR) changes in these patients. Therefore, we compared the cerebral blood flow velocity (CBFV) responses during different vasoregulatory challenge...

journal_title：Acta neurologica Scandinavica

authors： Bönöczk P,Panczel G,Nagy Z

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Bilateral hippocampal abnormality is frequent in mesial temporal lobe sclerosis and might affect outcome in epilepsy surgery. The objective of this study was to compare the lateralization of interictal and ictal scalp EEG with MRI T2 relaxometry. MATERIAL AND METHODS:Forty-nine consecutive patients with intr...

journal_title：Acta neurologica Scandinavica

authors： Okujava M,Schulz R,Hoppe M,Ebner A,Jokeit H,Woermann FG

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD. MATERIAL AND METHODS:Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up. RESULTS:The hazard ratio (HR) for mortality in...

journal_title：Acta neurologica Scandinavica

authors： Hughes TA,Ross HF,Mindham RH,Spokes EG

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Therapy of acute relapses in multiple sclerosis with corticosteroids (CC) remains uncertain with respect to route, dosage and effectiveness. This makes the treatment of relapses a clinical field where 'shared decision-making (SDM)' could be of advantage for the patients. A prerequisite for SDM is the provisi...

journal_title：Acta neurologica Scandinavica

authors： Köpke S,Heesen C,Kasper J,Mühlhauser I

更新日期：2004-07-01 00:00:00

abstract：:We described a patient with progressive non-syndromic hearing loss (NSHL) harboring the A3243G mutation in the mitochondrial DNA (mtDNA). Muscle biopsy showed scattered ragged-red, cytochrome c oxidase negative fibers, whereas the biochemical analysis of the mitochondrial respiratory chain complexes was normal. Restri...

journal_title：Acta neurologica Scandinavica

authors： Mancuso M,Filosto M,Forli F,Rocchi A,Berrettini S,Siciliano G,Murri L

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:A confident and accurate diagnosis of multiple sclerosis (MS) is important, but a specific diagnostic test for the disease does not exist. The traditional diagnostic criteria of Poser et al. were published in 1983, and recently, McDonald et al. recommended new criteria for the diagnosis of MS. PATIENTS AND ...

journal_title：Acta neurologica Scandinavica

authors： Fangerau T,Schimrigk S,Haupts M,Kaeder M,Ahle G,Brune N,Klinkenberg K,Kotterba S,Möhring M,Sindern E,Multiple Sclerosis Study Group.

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:Many studies have shown that nitric oxide (NO) and growth factors including insulin growth factors (IGFs) may be involved in the pathogenesis of multiple sclerosis (MS) and neurodegenerative diseases. Our previous studies suggested a relationship between cerebrospinal fluid (CSF) NO metabolites (nitrates and...

journal_title：Acta neurologica Scandinavica

authors： Pirttilä T,Vanhatalo S,Turpeinen U,Riikonen R

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). BACKGROUND:RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. METHODS:RR...

journal_title：Acta neurologica Scandinavica

authors： Gurevich TY,Groozman GB,Giladi N,Drory VE,Hausdorff JM,Korczyn AD

更新日期：2004-04-01 00:00:00